Cardiotoxicity under capecitabine treatment

Commentary by Dr Anton Snegovoy

In the study by Kwakman et al. ("Incidence of capecitabine-related cardiotoxicity in different treatment schedules of metastatic colorectal cancer: A retrospective analysis of the CAIRO studies of the Dutch Colorectal Cancer Group"), large clinical data shows the prevalence of cardiotoxicity under capecitabine treatment. Cardiovascular complications under fluoropyrimidines have already been described comprehensively in the literature; according to some data, the frequency of these complications can reach 10% (Frickhofen N, Beck FJ, Jung B, Fuhr HG, Andrasch H, Sigmund M. Capecitabine can induce coronary syndrome similar to 5-fluorouracil. Ann Oncol 2002; 13: 797–801). The interest of the study by Kwakman et al. is also connected with the fact that …


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About the editors

Dr. Matti S. Aapro: Editor-in-Chief

Dr. Matti Aapro received his medical degree from the Faculty of Medicine, University of Geneva, Switzerland. He was a fellow...

Dr Florian Scotté - Section Editor

Florian Scotté MD PHD is a medical oncologist in the Department of Oncology at the Georges Pompidou European Hospital, where...

Dr Carla Ripamonti - Section Editor

Carla Ida Ripamonti, M.D. specializes in medical oncology and clinical pharmacology. She is currently the Head of Supportive Care in...

Dr Ricardo Caponero - Section Editor

Dr Ricardo Caponero graduated in Medicine from Universidade de São Paulo, in 1984. Followed by a Fellowship in Radiotherapy at...

Dr Anton Snegovoy - Section Editor

ACADEMIC POSITIONS: Senior Research Associate, the Department of Research of New Anticancer Drugs with Out-patients Chemotherapy Unit, N.N.Blokhin Russian Cancer...

Dr Martin Chasen - Section Editor

Dr. Martin Chasen is currently the Medical Director of Palliative Care, at WOHS (William Osler Health System), previously Medical Director,...

Dr. Karin Jordan - Section Editor

Dr. Karin Jordan graduated from Martin Luther University of Halle-Wittenberg, Germany, after internships in the bone-marrow transplantation program at the...

Dr Jørn Herrstedt - Editorial Board Member

Jørn Herrstedt, MD, DMSci, is Professor in Clinical Oncology at the University of Southern Denmark and Senior Consultant at the...

Dr Andrew Bottomley – Editorial Board Member

Andrew Bottomley is a Chartered Psychologist and Fellow of the British Psychology Society United Kingdom (U.K.). Dr Bottomley has spent...

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