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Bisphosphonates in the Adjuvant Treatment of Breast Cancer

M.C. Winter, R.E. Coleman

Clinical Oncology, Volume 25, Issue 2, February 2013, Pages 135–145

Editors' comments: Dr. A.Snegovoy

Bisphosphonates first changed the fate of patients with bone metastases, allowing not only improve the quality of life, but also indirectly affect the effectiveness of treatment. Today bisphosphonate therapy is an integral part of a multimodal treatment concept bone metastases.
Interestingly, the evolution of bisphosphonates associated with evolution therapeutic effect, the influence on the development of osteoclasts to the antitumor effect.
This article examines the important issues associated with bisphosphonate therapy. This use in adjuvant settings and preventive mode of metastatic process, and that is very important for osteoporosis during ca