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Clinical classification of cancer cachexia: phenotypic correlates in human skeletal muscle.

Johns N, Hatakeyama S, Stephens NA, Degen M, Degen S, Frieauff W, Lambert C, Ross JA, Roubenoff R, Glass DJ, Jacobi C, Fearon KC.

PLoS One. 2014 Jan 3;9(1):e83618.

Editors' comments: Dr. Ricardo Caponero

Cachexia affects the majority of patients with advanced cancer and is associated with a reduction in treatment tolerance, response to therapy, and duration of survival. Muscle fibre size, biochemical composition and pathway phenotype can vary according to whether the diagnostic criteria for cachexia are based on weight loss alone, a measure of low muscularity alone or a combination of the two.
Combining the diagnostic criteria can result in a more effective treatment of cachexia.