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Factors Affecting Quality of Life at Different Time Points since Treatment in a Sample of Men with Localized Prostate Cancer: The Unique Influence of Treatment Decision Making Satisfaction, Personality, and Sexual Functioning

David E. Victorson, Stephanie Schuette, Benjamin D. Schalet, Shilajit D. Kundu, Brian T. Helfand, Kristian Novakovic, Nathaniel Sufrin, Michael McGuire, Charles Brendler

The Journal of Urology, Available online 31 May 2016



Using patient-reported outcomes measures, we identified the most informative set of factors associated with quality of life (QOL) in a large sample of men treated for localized prostate cancer.


We examined the relationships between QOL (FACIT) and hypothesized variables using a sample of men diagnosed with localized prostate cancer who represented different time points since treatment (<12 months: n=70; 1-3 years n=344; 3-5 years n=291; >5 years n=97). Correlative measures included sub-scales from the Memorial Anxiety Scale for Prostate Cancer (MAX-PC); short forms from the Patient Reported Outcomes Measurement Information System (PROMIS) and Surgical Outcomes Measurement System (SOMS); Treatment Decision-Making Satisfaction Scale (TDM-SATS); and sub-scales of the Big Five Inventory of personality (BFI).


QOL was significantly associated with hypothesized variables across different time cohorts. In regression models, several factors accounted for a majority of the variability in QOL scores depending on time since treatment (47%, 22%, 29%, and 27%, respectively). Upon examining the unique contribution of these variables, treatment decision making satisfaction was the only one to have a significant (p<.01) and unique contribution to QOL across all time cohorts (standardized coefficients = .33, .27, .31, .49, respectively). In the 1-3 year since treatment cohort, erectile function and neurotic personality style also had unique associations with QOL (standardized coefficients = .25, -.20, respectively).


When considering a man’s short and longer term QOL following treatment for localized prostate cancer, our findings highlight the importance of treatment decision making satisfaction, erectile function, and personality.

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