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Phase 3 Trial of Domiciliary Humidification to Mitigate Acute Mucosal Toxicity During Radiation Therapy for Head-and-Neck Cancer: First Report of Trans Tasman Radiation Oncology Group (TROG) 07.03 RadioHUM Study
Andrew Macann, FRANZCR, Tsien Fua, FRANZCR, Chris G. Milross, Sandro V. Porceddu, Michael Penniment, FRANZCR‖, Chris Wratten, FRANZCR, Hedley Krawitz, FRANZCR, Michael Poulsen, FRANZCR, Colin I. Tang, FRANZCR, Randall P. Morton, K. David Hay, Vicki Thomso
International Journal of Radiation Oncology*Biology*Physics, Volume 88, Issue 3, 1 March 2014, Pages 572–579
Editors' comments: Dr. Ricardo Caponero
Using a humidifier during head and neck radiation therapy combines the principles of moist wound care with the principles of domiciliary humidification, developed in respiratory medicine. The TROG 07.03 phase 3 multisite trial has provided efficacy signals consistent with a role for humidification in reducing symptom burden from mucositis. These signals were seen across clinician-reported, patient-reported, and independent outcomes. The influence of humidification compliance on the results moderates recommendations regarding its practical utility.