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State of the art for cardiotoxicity due to chemotherapy and to targeted therapies: A literature review

Critical Reviews in Oncology/Hematology, 1, 88, pages 75 - 86

Abstract

Cardiotoxicity is a common complication of many anti-cancer agents and it remains a major limitation, strongly impacting the quality of life and the overall survival, regardless of the oncologic prognosis.

Cardiotoxicity may occur during or shortly after treatment (within days or weeks), or it may become evident months, and sometimes years, after completion of chemotherapy.

Cardiotoxicity associated with cancer therapies can range from asymptomatic subclinical abnormalities, including electrocardiographic changes and temporary left ventricular ejection fraction decline, to life-threatening events such as congestive heart failure or acute coronary syndromes.

The aim of this review is to summarize potential cancer chemotherapeutics-related cardiovascular toxicities in adult cancer-patients and to suggest monitoring and treatment options for each agent, that can serve as a tool in the clinical practice.

Keywords: Cardiotoxicity, Anticancer therapy, Cardiovascular toxicity, Targeted therapies, Chemotherapy.

Footnotes

Medical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I – GM Lancisi – G Salesi, Ancona, Italy

lowast Corresponding author at: Medical Oncology Unit, Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I – GM Lancisi – G Salesi di Ancona, Via Conca 71, 60126 Ancona, Italy. Tel.: +39 071 5965715; fax: +39 071 5965053.