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Supportive Cryotherapy: A Review From Head to Toe

Kunal C. Kadakia, Shaina A. Rozell, Anish A. Butala, Charles L. Loprinzi

Journal of Pain and Symptom Management, Volume 47, Issue 6, June 2014, Pages 1100-1115 


Editors' comments: Dr. Ricardo Caponero

Available evidence suggests that regional hypothermia decreases the burden of chemotherapy-related oral mucositis, alopecia, ocular toxicity, and onycholysis. The major limitations of studies include the absence of blinded control groups and variable clinical end points. This paper provides a meaningfull review of the state of the art in this topic.