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Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2.
Barton DL, Liu H, Dakhil SR, Linquist B, Sloan JA, Nichols CR, McGinn TW, Stella PJ, Seeger GR, Sood A, Loprinzi CL.
J Natl Cancer Inst. 2013 Aug 21;105(16):1230-8.
Editors' comments: Dr. Ricardo Caponero
Fatigue is one of the most distressing symptoms in patients with cancer. Few randomized trial demonstrate any pharmacological activity in fatigue treatment and pharmacological interventions remain investigational despite some benefits in symptom control with modafinil or methylphenidate. This trial shows a statistical significant and a clinical meaningful benefit.