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Complex clinical cases in breast cancer

Presentation by Dr. Laurent Zelek at the TAO Congress on 19/20 November 2015

TAO15 - LAURENT ZELEK - New therapies and supportive care in breast cancer-HD

Treatment-induced toxicities represent a major problem in cancer therapy. Toxicities which cannot be managed by curative treatment or supportive care frequently lead to an interruption or discontinuation of cancer therapy, which has an impact on efficacy. In the context of the session dedicated to “New therapies and supportive care in breast cancer”, Dr. Laurent Zelek presents clinical cases in which cancer therapy was impeded by toxic effects:

  • A Patient with HER2-positive breast cancer who received docetaxel, trastuzumab and pertuzumab and developed severe skin toxicities

  • A Patient with RH+ breast cancer who received exemestane and everolimus and developed pneumopathy

  • A Patient with a history of breast cancer and docetaxel-induced residual neuropathy; under treatment with irinotecan, fluorouracil and cetuximab for colon cancer, she developed pulmonary embolism and skin toxicities

  • An overweight and physically inactive patient who gained weight during chemotherapy


Dr. Laurent Zelek, Hôpital Avicenne, Bobigny, France


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