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ESMOPharma 2013 (ECC 2013): Dr Florian Scotté

Predictive Factors for Survival in Early Trials

ESMOPharma 2013 (ECC 2013): Dr Florian Scotté


Prognostic factors for mortality within 90 days in phase I oncology trial [2013 ECC, Abs 1745].

The inclusion of patients in phase I of therapeutic trials is often risky due to the poor prognosis in the relatively short term for certain diseases. Several predictive criteria have already been suggested: haemoglobin, albumin and lactate dehydrogenase (LDH) levels, performance status (PS), as well as the number of metastatic sites. These criteria are used by various international centres recognized for their management of cancer patients (Bachelot T et al. Ann Oncol 2000; Garrido-Laguna I et al. Cancer 2011; Arkenau HT et al. Brit J. Cancer 2008).

A retrospective study conducted in the Netherlands on 371 patients included in early trials attempted to evaluate these factors in order to create a specific prognostic scale. The Antoni Van Leeuwenhoek (AVL) score thereby calculated would be used to select patients who would be amenable to inclusion in early trials. The connection between risk factor and prognosis was highly significant (0.001 to < 0.0001) for each of the five criteria previously cited.

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