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MASCC Miami Florida June 2014: Dr Florian Scotté
Kidney Failure a Risk Factor for Febrile Neutropenia in NHL
By Vincent Launay-Vacher
Li X et al., abstr. 0230
This American case-control study examined types of comorbidity that are associated with an increased incidence of febrile neutropenia in 1,540 breast cancer (BC) patients and 869 non-Hodgkin lymphoma (NHL) patients. Between 2007 and 2011, each patient that presented with febrile neutropenia during the first chemotherapy treatment was matched with 4 patients with respect to the type of cancer, metastases, chemotherapy regime, age bracket, and sex. The analysis was adjusted for potential confounding factors (GCSF (Granulocyte-Colony Stimulating Factor) prophylaxis, previous hospitalization, surgery, etc.).
In breast cancer patients, osteoarticular inflammation was associated with an increase in the risk of the onset of febrile neutropenia (Adjusted Odds Ratio [aOR] = 1.85; [1.07-3.18]). In NHL patients, kidney failure was identified as the risk factor for febrile neutropenia in this study (aOR = 2.25; [1.23-4.11].
NHL and breast cancer: risk of febrile neutropenia as it relates to comorbidity at the start of chemotherapy