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SIOG Clinical Guidelines on Use of Anthracyclines in the Elderly (2010)
Matti Aapro, Chantal Bernard-Marty, Etienne Brain, Frans Erdkamp, Krzysztof Krzemieniecki, Robert Leonard, Ana Lluch, Silvio Monfardini, Mary Ryberg, Pierre Soubeyran, Ulrich Wedding., The International Society of Geriatric Oncology (SIOG) Clinical Guidel
The SIOG Anthracyclines in the Elderly Task Force is set up to issue recommendations for the use of anthracyclines in geriatric cancer patients. This is of particular relevance, as this first-line therapy option for non-Hodgkin's lymphoma and breast cancer (both metastatic and early forms) can cause chronic heart failure as side effect. Obviously, in particular the older cancer patients will have an increased risk for such unwelcome side effects.
The Task Force has published an expert position paper on the cardiotoxicity of this drug in the elderly patient (Annals of Oncology, 2010, 22 (2): 257-67). In this paper the factors that increase the risk of a cardiotoxic effect are described and alternative modes of administration that may reduce cardiotoxicity are discussed.