You are here

Case Report: Cutaneous toxicity after rechallenge with pemetrexed

Presentation by Marine Sroussi at the TAO Congress on 19/20 November 2015


The diagnosis of the 51-year-old male patient is lung adenocarcinoma without mutation in EGFR, ERBB2, KRAS or BRAF and without ALK translocation; he has metastases in the brain, bones, node, adrenal gland and lung.

He receives 4 cycles of pemetrexed and radiotherapy to the bone, followed by 3 cycles of pemetrexed and bevacizumab, then several cycles of chemotherapy with various other agents. During treatment with crizotinib, he develops photosensitivity, photoallergy and thrombosis. After rechallenge with pemetrexed, he suffers from fever, dyspnea, cough, sputum, grade 2 diarrhea and grade 2 erythematous rash. Marine Sroussi and the expert panel discuss the toxicities observed in this case, mainly focusing on dermatologic complications, which are seen more and more with the new PD-1 inhibitors, tyrosine kinase inhibitors and others.

This case report is part of the programme “AERIO meets the experts” by the French Association of Residents in Oncology (AERIO) in collaboration with an expert panel (Dr. Mario Dicato, Luxembourg Medical Center, Luxembourg; Dr. Richard Gralla, A. Einstein School of Medicine, New York, USA; Dr. Jeffrey Crawford, Duke Cancer Center, Durham, USA; Dr. Pere Gascon, Hospital Clinic, Barcelona).

Marine Sroussi, Oncology Resident, European Hospital Georges-Pompidou, Paris, France

Search this site

Featured videos

Free access to ebooks on cachexia and CINV


Prevention of nausea and vomiting in
adult cancer patients receiving tumour-
directed therapy – 2017 update –

Cancer cachexia: mechanisms and progress in treatment


Stay up-to-date with our monthly e-alert

If you want to regularly receive information on what is happening in Quality of Life in Oncology research sign up to our e-alert.

Subscribe »

QOL (Quality of Life) newsletter e-alert

Quality of Life promotional video

Made possible by an educational grant from Helsinn

Helsinn does not have any influence on the content and all items are subject to independent peer and editorial review

Society Partners

European Cancer Organisation Logo