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Ghrelin in the skeletal muscle: more than just hunger (part 2)

Questions and Answers with Dr. Andrea Graziani, recorded at the Int. SCWD Conference on Cachexia on 05 December 2015

Cachexia15 part1 Teil2-HD

In this question and answer session, Dr. Andrea Graziani (Milan, Italy) first described the mechanisms behind the use of ghrelin in clinical trials. Acetylated ghrelin is used in clinical trial and thus targets both receptors, including GHSR1, to confer effects on appetite as well as skeletal muscle.

Next, Dr. Graziani indicated that fasting is the major regulation mechanism of ghrelin. Most acetylated and unacetylated ghrelin is manufactured in the stomach, and current thought is that the regulation of both types of ghrelin is similar. Differences between the acetylated and unacetylated forms of ghrelin are controlled by ghrelin-O-acetylatransferase (GOAT), the ghrelin-activating enzyme; however, the specifics surrounding the regulation of acetylated and unacetylated ghrelin are not yet well described.

Dr. Graziani concluded by describing how manipulating the diet can change the fatty acid bound to the acetylated ghrelin, though different short fatty acids appear to have no effect on the properties of the acetylated ghrelin.

This video has been recorded at the 8th Int. Conference on Cachexia, Sarcopenia and Muscle Wasting on the 5th of December 2015 in Paris, France.

The symposium on Cachexia at the Int. SCWD Conference 2015 was sponsored by Helsinn SA.

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