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Management of Targeted Therapies: digestive toxicities
By Christophe Tournigand, recorded at TAO (Transatlantic Oncology meeting), Nov 20-21, 2014, Paris
Christophe Tournigand provides an overview of the most common toxicities of the digestive system as well as the drugs and targeted therapies that cause them. These toxicities are important as they can require dose reductions, have an impact on pharmacokinetics and affect the patient’s quality of life. Hepatic toxicities can be caused by direct toxicity on the hepatic parenchyma, drug interaction, immunoallergic mechanisms or alteration of the underlying hepatic function. Other toxicities include pancreatic toxicities, perforations and diarrhea. Diarrhea is the most problematic toxicity for the patients and should not be underestimated as it can lead to dehydration and fatigue.
Christophe Tournigand, Hôpital H. Mondor, Créteil, France