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Session on G-CSF: receptors and mutations
By Mario Dicato, recorded at TAO (Transatlantic Oncology meeting), Nov 20-21, 2014, Paris
Mario Dicato reviews receptors and mutations with regard to G-CSF. He chose this topic, because the same question arises in any discussion concerning G-CSF: Can G-CSF cause leukemia? Patients with severe congenital neutropenia (SCN, Kostmann syndrome) and mutations in the G-CSF receptor have an increased risk for the development of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Therefore, genetic evaluation is recommended in patients with chronic neutropenia.
Mario Dicato, Centre Hospitalier du Luxembourg